According to this systematic-review meta-analysis, beta-thalassemia carriers could be less affected by CO VID-19 than the general population and more susceptible to die from COVID-19 or one of its consequences. Should people with thalassemia take vitamins and mineral supplements during the COVID-19 pandemic? Future Sci OA. Beta thalassemia minor or thalassemia trait. Newborn screening practices and alpha-thalassemia detection United States, 2016. COVID-19: Beta-Thalassemia Subjects Immunised? - Preprints Globally, the prevalence of COVID-19 in people with beta-thalassemia specifically appears to be lower than the general population. If you have minor or no symptoms, your provider may suspect thalassemia based on the results of a routine blood test. Some of the publications discussing pregnancy in a patient with COVID19 infection mentioned thalassemia, thalassemia trait, and thalassemia minor in the list of comorbidities in the description of their included patients characteristics. Its more common in many of the same parts of the world as alpha-thalassemia. In spite of those terrible limits, this systematic-review meta-analysis opens the way to the confirmation of a possible protection/immunity of beta-thalassemia carriers against COVID-19 concerning incidence and ICU admission markers [7,8]. Looking at a small sample group early on in the pandemic, the overall mortality rate of those with thalassemia from a COVID-19 infection was 18.6%, compared with a mortality rate of 4.71% in the general population. Patients with beta-thalassaemia increase the risk of bacterial infections, particularly Burkholderia pseudomallei (Bp), the causative agent of melioidosis in Thailand. Thalassemia and Coronavirus (COVID-19): Complications - Verywell Health An official website of the United States government. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. The information in this article is current as of the date listed. A Practical Approach to the Management of Cancer Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic: An International Collaborative Group. COVID Natural Immunity: What You Need to Know Blood transfusions are a mainstay of treatment for some people with thalassemia. The COVID-19 pandemic may affect both the treatment of thalassemia in general and how COVID-19 is treated in people with thalassemia who become infected. Whats the outlook for people who have beta thalassemia? Heavy alcohol drinking is known to further aggravate anemia. The forgotten people with thalassemia in the time of COVID-19: South Asian perspective. Vitamin and mineral supplementation for -thalassemia during COVID-19 pandemic. The results align with the results of other studies from countries around the world. Many patients with haemoglobinopathies, including thalassaemia and sickle cell disease, are at increased risk of developing severe complications from the coronavirus disease 2019 (COVID-19). Alpha-thalassemia occurs when your body has trouble producing hemoglobin alpha. Blood. The https:// ensures that you are connecting to the Working with your healthcare team to keep up with thalassemia treatments, getting vaccinated, and monitoring and treating for complications early if COVID-19 symptoms do develop are the recommended strategies to staying healthy through the pandemic. There are two damaged genes. Some research findings have suggested that people with blood types A and AB are more susceptible to contracting COVID-19, while those with blood type O are less likely to test positive for the virus. To begin, think of something you've had time to do that you'd otherwise not have time for, or something you learned. Other types of thalassemia cause more severe symptoms that can be found earlier in life, usually before a child is . The ways that a healthcare provider diagnoses thalassemia depends on the type of thalassemia you have. 2020 Oct;13(10):1081-1092. doi: 10.1080/17474086.2020.1819785. They also had a higher chance of developing severe symptoms but didnt have higher rates of ICU admission. Genetic correction of concurrent - and -thalassemia patient-derived pluripotent stem cells by the CRISPR-Cas9 technology. This can make them very anaemic (tired, short of breath and pale). Blood clots are fairly common with COVID-19, and many physicians view it as a disease of blood vessels. "As an individual, you have your blood typethere's nothing you can do about it.". What We Know, 25% chance their child wont have thalassemia trait, 50% chance their child will have thalassemia trait, 25% chance their child will have a severe form of thalassemia. If you have concerns, speak with a doctor or healthcare professional about your individual risks. Unauthorized use of these marks is strictly prohibited. But some researchers believe it may, based on the primarily mild symptoms of COVID-19 in people with thalassemia found in a study out of Southeast Asia. 2020;95(8):E208-E210. States with religious and philosophical exemptions from school immunization requirements. Blood types can also serve as receptors for viruses and bacteria, and that could be another factor, explained Dr. Russo, there may be some other, completely different component of type O blood that works to prevent infection. While it's always helpful to know your blood type, most people won't necessarily need to know that information. Chowdhury SF, Anwar S. Management of hemoglobin disorders during the COVID-19 pandemic. People with beta thalassemia minor might never know they have the disease. Abstract. Biochemistry, hemoglobin synthesis. Bender MA, et al. The COVID-19 pandemic is putting a lot of burden on healthcare . The proposed measures and strategies may be useful as a blueprint for other disorders which require regular hospital visits, as well as for the timely adaptation of patient care during similar future pandemics. Blood type has been identified as a risk factor in many diseases, from cancer to venous and arterial thromboembolism. Summary document for interim clinical considerations for use of COVID-19 vaccines currently authorized or approved in the United States. Farid Y, et al. This condition can cause abrupt changes in blood pressure or heart rate that may worsen a person's condition during a COVID-19 infection. 2020 Jun;25(6):e936-e945. Jean-Mignard E, et al. Marhaeni W, Felicia FV, Sumadi Jap AL, Hartoyo E, Andayani P. Front Med (Lausanne). Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality. Respiratory failure may occur just as with people who do not have thalassemia. An exception is for people who have already begun the conditioning process for a stem-cell transplant. What Research Says About the Link Between COVID-19 and Blood Type, What the Blood Link Research Means for You, Omicron vs. Delta: How the 2 COVID-19 Variants Compare, ShinglesHerpes ZosterInfection May Be Linked to the COVID-19 Vaccine, Can COVID-19 Cause Diabetes? Beta-thalassemia trait is less common. Yet, no matter how difficult the trial, there are often positive points. marion.cook@wanadoo.fr. Should you get a COVID vaccine if you have beta thalassemia? These antigens help prompt a response from your body's immune system. Pregnancy outcomes among women affected with thalassemia traits. Indian Pediatr. People with thalassemia trait dont usually have symptoms. 2020;91(3):e2020026. Transfusion. Thalassemia is a hereditary disorder that affects the production of hemoglobin. doi:10.23750/abm.v91i3.10155, De Sanctis VD, Canatan D, Corrons JLV, et al. Its severity varies greatly between people. Beta thalassemia major (Cooley's anemia). These diseases usually occur only in people who have at least two abnormal . Blood tests can reveal the number of red blood cells and abnormalities in size, shape or color. Coronavirus: People with thalassemia face "blood shortage", appeal for Frequency of COVID-19 Antibodies in Patients With Hereditary (2022). Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Research suggests that people with thalassemia may be at a slightly increased risk of contracting COVID-19, especially those who are transfusion dependent which puts them at an increased risk of exposure to the virus. Several genes contribute to the production of hemoglobin. Without enough hemoglobin, your red blood cells die more quickly, and your organs and tissues dont get enough oxygen. Iron overload due to repeated transfusions is the cause of many complications seen with thalassemia, and therefore many people are treated with iron chelation therapy. If you do, theyll be mild. 2021;16(1):114.doi:10.1186/s13023-021-01757-w. U.S. Food & Drug Administration. But because reinfection is possible and COVID-19 can cause severe medical complications, it's recommended that people who . Healthline Media does not provide medical advice, diagnosis, or treatment. Am J Hematol. As a whole, experts recommend that peopleregardless of blood typekeep following CDC guidelines to prevent the spread of COVID-19. Thalassemia trait, aka thalassemia minor, usually doesnt cause health issues. Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality. ; 4 Department of Clinical and Biological Sciences . We avoid using tertiary references. Thalassemia also increases the likelihood to form blood clots. This means you have lower levels of hemoglobin, which could result in mild anemia. Learn more about COVID-19 vaccination for people with beta-thalassemia or beta-thalassemia trait. About 1.5% of the worlds population carry HBB mutations that cause beta thalassemia. The Centers for Disease Control and Prevention (CDC) and the Thalassemia International Federation urge people with thalassemia to get the COVID-19 vaccine. For people living with thalassemia, because too much iron may build up in the blood, foods high in iron may need to be limited. You can learn more about how we ensure our content is accurate and current by reading our. 2021 Mar 1;16(1):114. doi: 10.1186/s13023-021-01757-w. Parakh N, Pahuja S, Singh V, Kumar N, Chandra J. J Paediatr Child Health. Last medically reviewed on August 23, 2022. Six had their spleens removed. Some people have been re-infected multiple times with the virus, while others appear to have avoided the virus entirely. Affiliations 1 Department of Clinical Sciences and Community Health, Universit Degli Studi di Milano, Milan, Italy. There are four types of alpha thalassemia, and two main types of beta thalassemia. So, its important to know your status. Let's look at why and how to get support to stop drinking: While not as serious as other causes of chest pain, anemia-related chest pain can be a sign that your current treatment plan isn't working. 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